A breakthrough study has uncovered a hidden player in Parkinson’s disease—24-OHC, a cholesterol metabolite that fuels the ...
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The link between renal failure and Parkinson's disease: Researchers illuminate the underlying mechanismsLewy body diseases (LBDs) are a class of debilitating neurodegenerative disorders linked to the abnormal aggregation of the protein α-synuclein in nerve cells. When misfolded, this protein can produce ...
At the Rutgers American Parkinson Disease Association Center for Advanced Research —one of only nine such centers—we don’t just seek to treat the symptoms of Parkinson’s but to cure it. By focusing on ...
▎药明康德内容团队编辑 帕金森病（Parkinson's Disease, ...
研究团队通过大规模基因分析发现，FAM171A2基因的多个变异与帕金森病风险显著相关（图1A）。在帕金森病患者的中脑和脑脊液中，FAM171A2蛋白水平显著升高，且与α-syn纤维的聚集程度呈负相关（图1G）。这意味着，FAM171A2的表达越高，患 ...
Researchers suggest drugs that prevent cholesterol from being converted to 24-OHC might therefore be an effective treatment for Parkinson's disease.
Researchers from Osaka University found that peristaltic pump flow mechanically breaks supersaturation to induce amyloid ...
A photothermal, nanoparticle-based deep brain stimulation system restored motor skills in mice with Parkinson’s-like disease ...
NKGen takes a meaningful step towards potential treatment for frontotemporal dementia (“FTD”) patients with limited treatment options.SANTA ANA, Calif., Feb. 21, 2025 (GLOBE NEWSWIRE) -- NKGen Biotech ...
本研究通过光镊实验，发现α-syn纤维是一种高度刚性的生物聚合物，且其形变和断裂特性具有显著的异质性。传统方法（如酶切，超声等）通常得到的是大量纤维平均后的稳定性信息，而本研究提供了单根纤维的力学测量结果，揭示了单根纤维在力学稳定性上的显著差异。这一 ...
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