英国药理学：小檗胺和瓦巴因靶向Na+K+- atp酶与索拉非尼协同抑制肝癌 多激酶抑制剂索拉非尼是治疗晚期肝细胞癌(HCC)的一线药物。然而，肝癌患者对 ...

This study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights ...

Mutations in the gene that encodes a protein called adenine nucleotide translocator ... generate most of the ATP needed to fuel body's cells and play an important role in high-energy demanding ...

Researchers aim to apply these findings to produce more complex ATP- and ADP-coupled biomolecules to investigate their role and significance in cell function. “Our ultimate goal is to elucidate their ...

In general, ATP concentrations must be maintained above 1 mM, with a high ATP/ADP.Pi ratio, in order to sustain the energy needed for RNA and nucleotide biosynthesis.

When ATP or ADP were added, this further increased gripping and friction, indicating two mechanisms of motor-DNA interaction -- nucleotide-dependent and nucleotide-independent.