Five signaling subtypes identified by NMF clustering. Subtype 5 (high APsig) correlates with immune-rich "hot" tumors, while Subtype 2 (low APsig) exhibits metabolic reprogramming and hypoxia. High ...

Blood tests are a common, yet often painful, step in health care. But what if we could skip the needles altogether? Saliva and blood contain many of the same biomarkers, and collecting spit is as ...

The coffee paradox in adenosine-mediated antidepressant action. Depression (left) and coffee consumption (right) are both linked through adenosine signaling (center), creating a pharmacological ...

A recent study by researchers at the University of Florence and collaborators has demonstrated the efficacy of MRS-3997, a dual adenosine A2A/A2B receptor agonist, in reducing brain damage and ...

A 1 AR Brain (cortex, hippocampus, cerebellum), spinal cord, eye, adrenal gland, atria, liver, kidney, adipose tissue, salivary glands, esophagus, colon, atrium and ...

Researchers from the Chinese Institute for Brain Research, the Chinese Academy of Medical Sciences, and their collaborators have identified adenosine as the driving force behind the rapid, fast-acting ...