We have reported observing aldosterone breakthrough in the course of relatively long-term treatment with renin–angiotensin (RA) system inhibitors, where the plasma aldosterone concentration (PAC ...

To the Editor: In the editorial on heparin (New England Journal of Medicine August 8, 1968, p. 320) several biologic effects of this drug are enumerated, but its aldosterone-suppressive effect, al ...

The renin-angiotensin-aldosterone system has long been recognized as playing a major role in cardiovascular disease by its involvement in the pathophysiology and maintenance of essential ...

Purpose: The clinical benefits, adverse effects, pharmacokinetics, and recommendations for the appropriate use of the aldosterone antagonists spironolactone and eplerenone in patients with heart ...

Aldosterone, a hormone made by the adrenal glands, has been linked to kidney disease in people with diabetes, and now in those without it. Skip to Main Content. Mental Health. research.

Aldosterone is associated with an increased risk of chronic kidney disease progression and the development of end-stage kidney disease, according to data published in the European Heart Journal ...

However, the development of such a drug has been thwarted by the 93% sequence similarity between aldosterone synthase and the final enzyme required for cortisol synthesis, 11β-hydroxylase. 23,24 ...

An op-ed published in February by Tom Frieden, MD, MPH, former director of the CDC, described hypertension as “the deadliest but most neglected and widespread pandemic of our time” — and ...

Lorundrostat, a novel therapy which blocks the production of aldosterone from the adrenal glands, demonstrated clinically meaningful and sustained reductions in blood pressure in 1,083 patients ...

Hyperaldosteronism is when your adrenal glands make too much aldosterone hormone. Learn about the causes, symptoms, and treatment options for this condition today.

Aldosterone acts as a mediator of hypertension, heart failure and kidney disease, and aldosterone synthase inhibitors (ASIs) have emerged as an alternative approach for the treatment of some of these ...