is an antibody conjugation technology that replaces the native antibody glycan with a therapeutic payload, using enzymes and metal-free ‘click’ chemistry. Starting from any off-the-shelf ...

The second section describes the applications for bacterial glycosidases in antibody glycan engineering and glycan analysis of glycoproteins. Following the concluding section, we present our ...

Japanese researchers investigated how polyamines affect the functional profile of monoclonal antibodies and their production from CHO cells, and found that spermidine supplementation contributes ...

At the heart of these interactions is the Asn297-linked glycan on the Fc region of IgG antibodies. This glycan facilitates binding to Fc receptors, triggering immune responses. The newly ...

Leader in manufacturing reagents and critical components for biomedical research to leverage Etcembly’s AI platform to ...

Glycosidases as glycan engineering tools: IgG glycan engineering EndoS-treated pathogenic antibodies become therapeutic in neuromyelitis optica. IgG inhibition of a monoclonal antibody therapy can ...

Glycan composition is a critical quality attribute that affects the stability, safety and efficacy of protein therapeutics. As glycosylation profiling requirements evolve across drug development ...

but the role of these antibodies in vivo has been unclear. In the March 20 Nature, Xiping Wei and colleagues at the University of Alabama at Birmingham, US, show that HIV manages to escape the Nab ...

announced the launch of a new Released N-Glycan Assay for the in-depth profiling of IgG glycosylation. This new physico-chemical assay, developed by SSB’s subsidiary BioOutsource and offered in ...

JSKN003 is an anti-HER2 biparatopic ADC, which is developed inhouse with Alphamab's proprietary Glycan-specific conjugation platform. Compared with its ADC counterparts, JSKN003 demonstrated better ...