本研究揭示了ATG16L1通过其FIP200相互作用区(FIR)不仅直接结合FIP200的Claw结构域，还能作为非典型ATG8相互作用基序选择性识别哺乳动物ATG8家族蛋白。研究人员通过高分辨率晶体结构解析和细胞功能实验，证明ATG16L1与FIP200的相互作用对自噬通量至关重要，为理解自噬 ...

Autophagosomes are formed by membrane expansion and invagination, during which intracellular proteins, organelles, etc. are sequestered into autophagosomes. The sequestered materials are degraded upon ...

S. Pankiv et al., “p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy,” J Biol Chem, 282:24131–45, 2007. (Cited in 113 papers) Terje ...

Nutrient deprivation inhibits mTORC1 and activates AMPK, which then dephosphorylates or phosphorylates ULK1 at different sites, leading to the activation of the ULK complex and initiation of the ...