Autophagy is the engulfment of cytosol and organelles by double-membrane vesicles termed autophagosomes. Autophagosome formation is known to require phosphatidylinositol 3-phosphate (PI(3)P) and ...

Drs. Nobuo Noda (Director) and Tatsuro Maruyama (Researcher) et al. at the Institute of Microbial Chemistry (BIKAKEN, Tokyo, Japan) discovered that lipidated Atg8(1), the most famous factor that ...

Pre-autophagosome membrane captures damaged mitochondria and other cytosolic components to become an autophagosome. Autophagosome fuses with lysosome and the materials inside are degraded. Researchers ...

Autophagy leads to the lysosomal degradation of cytosolic components and organelles. The best understood role for autophagy is directing the removal of damaged or unwanted products. Autophagy can be ...