A feature of pancreatic cancer cells' surroundings determines whether they grow fast or become resistant to chemotherapy, a new study shows. The ability of these cancer cells to adapt quickly and ...

Researchers suggest targeting ECM-mediated regulation of autophagy levels could be used to sensitize pancreatic cancer to FDA-approved therapies.

A feature of pancreatic cancer cells' surroundings determines whether they grow fast or become resistant to chemotherapy, a new study shows. The ability of these cancer cells to adapt quickly and ...

Image Caption: CRISPR-Cas9 library identified XPR1 as a potential gene regulating autophagy. Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative ...

In the complex world of cancer biology, the term ‘autophagy’ has transitioned from a niche scientific phrase to a focal point of investigation for both prevention and treatment. Derived from Greek, ...

Hdy-7 directly binds to TrxR1/2, triggering ROS accumulation and p53 activation. Activated p53 negatively regulates mTORC1 signaling, which is one of the major kinases responsible for the ...

“The implication here is that if you inhibit autophagy you'd make this less likely to happen, i.e. when you kill cancer cells they would stay dead,” Andrew Thorburn, the senior author of the study and ...

An international research team led by Osaka University has identified a new mechanism crucial for the initiation of autophagy, a self-degradation process cells use to eliminate unneeded or damaged ...

Elenagen plus gemcitabine improves overall survival in platinum resistant ovarian cancer without increasing toxicity in Phase ...

Pancreatic cancer is a particularly aggressive and difficult-to-treat cancer, in part because it is often resistant to chemotherapy. Now, researchers at Stanford have revealed that this resistance is ...