Researchers suggest targeting ECM-mediated regulation of autophagy levels could be used to sensitize pancreatic cancer to FDA-approved therapies.

Sepsis, septic shock, and their sequelae are the leading causes of death in intensive care units, with limited therapeutic options. Disease resistance and tolerance are two evolutionarily conserved ...

Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...

Now, more than two decades later, researchers homed in on a mutation in the gene zinc finger homeobox protein 3 (ZFHX3), a transcriptional regulator that seems to mess with a cell’s ability to perform ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...

Josephine Thinwa shares her journey to becoming a physician scientist and how this led her to investigate the role of a neurologically important kinase in virus-induced autophagy. Just like people ...

As axonal mitochondria are lost, changes in the subunits of eIF2 are seen which hamper translation and autophagy and cause the accumulation of proteins in cells. Tokyo, Japan – Researchers from Tokyo ...

The autophagy process, a critical regulator of T-cell function, has been shown to control acute HIV-1 infection and play a crucial role also in HIV-1 disease pathogenesis. Moreover, previous studies ...

Does fasting guarantee weight loss? Is longer fasting always healthier? Can fasting detox the body or cure lifestyle diseases? An internal medicine expert busts common fasting myths many Indians still ...