Researchers suggest targeting ECM-mediated regulation of autophagy levels could be used to sensitize pancreatic cancer to FDA-approved therapies.

Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. Scientists have now uncovered possible novel functions for various autophagy genes, which may control ...

A feature of pancreatic cancer cells' surroundings determines whether they grow fast or become resistant to chemotherapy, a new study shows. The ability of these cancer cells to adapt quickly and ...

Research from investigators at Rutgers Cancer Institute of New Jersey and the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center, shows the intracellular process of ...

Autophagy leads to the lysosomal degradation of cytosolic components and organelles. The best understood role for autophagy is directing the removal of damaged or unwanted products. Autophagy can be ...

The cell recycling process, known as autophagy, is controlled by a complex group of proteins. This 3D image reveals the overall structure of the autophagy promoting complex, showing each of its ...

The mechanism of astrocytic autophagy plasticity plays a crucial role in AD. When the autophagy-regulating genes (LC3B and SQSTM1) in astrocytes are activated, Aβ is efficiently removed, which is ...

A feature of pancreatic cancer cells' surroundings determines whether they grow fast or become resistant to chemotherapy, a new study shows. The ability of these cancer cells to adapt quickly and ...

Researchers reveal how a nanomachine takes care of cleaning up inside the cell. To prevent our body's cells from overflowing with garbage and to keep them healthy, the waste inside them is constantly ...