Nature9 年
Recurrent activating mutations of CD28 in peripheral T-cell lymphomas
CD28 is the major co-stimulatory receptor in T cells which ... the T195P mutant in response to CD3 and CD86 co-stimulation and increased downstream activation of NF-κB by both D124V and T195P ...
Nature9 年
CD28 deletion improves obesity-induced liver steatosis but increases adiposity in mice
The CD28 costimulatory molecule is required for lymphocyte activation and for the development ... The observed correlations between bacterial 16S DNA, CD3 + T cell and epiAT mass support a direct ...
technologynetworks11 个月
GMP Human 4-1BB Ligand Protein for T, NK, and DC Cell Culture
or CD3/CD28 magnetic beads, along with the addition of relevant growth factors to activate T cells. During this process, the CD28-mediated co-stimulatory signal plays a central role. Multiple studies ...
来自MSN11 个月
Lymph node-like biomaterial scaffold for augmenting CAR-T cell therapy
Moreover, the research team adorned the scaffold with two pivotal signaling molecules for T cell activation—anti-CD3 and anti-CD28 antibodies—further emulating the antigen-presenting cells ...