CD4:CD8 ratios were determined and lymphocyte subsets were analyzed using CD3-, CD4-, CD8-, CD19- and CD56-reactive monoclonal antibodies and flow cytometry (Becton Dickinson, Franklin Lakes ...

Here we have designed a CAR, CD4CAR, which redirects the antigen specificity of CD8+ cytotoxic T cells to CD4-expressing cells. CD4CAR T cells derived from human peripheral blood mononuclear cells ...