钙离子（Ca²⁺）是T细胞信号转导的关键第二信使。不同钙通道与钙泵的组合可形成具有细胞类型特异性的钙信号模式，从而适配不同的生理功能。如油酸可通过调节ATP2a2抑制Treg细胞分化，而胞内钙水平升高也可增强初始CD4⁺ T细胞向Treg极化的敏感性 ...

Immune cells called double negative T cells are abundant in the intestine but have been poorly understood till date. In a ...

Researchers identified immune cells that attacked the neuronal protein C9orf72 in individuals with ALS, spurring new ...

Immune cells called double negative T cells are abundant in the intestine but have been poorly understood till date. In a ...

The brain and spinal cord were once thought to enjoy immune privilege, meaning they were believed to be largely insulated from immune activity elsewhere in the body. In recent years, however, ...

Breakthrough T1D (formerly JDRF), the Lupus Research Alliance, and the National Multiple Sclerosis Society today announce the recipients of the Common Mechanisms of Autoimmunity Insight Award, a ...

Exercise can help restore the immune system post- Covid, reducing symptoms like tiredness, joint pain and other long-term ...

Individuals with post-COVID syndrome had higher immune cell counts after receiving exercise-based rehabilitation vs. usual ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

Autoimmune diseases, such as multiple sclerosis (MS), inflammatory bowel disease (IBD), and rheumatoid arthritis (RA), affect millions of people worldwide. These conditions arise when the body's ...