编辑丨王多鱼排版丨水成文抗 PD-1 联合仑伐替尼（lenvatinib，一种多靶点受体酪氨酸激酶抑制剂）治疗在多种肿瘤中均显示出临床疗效，但潜在的免疫学机制尚不清楚。2025 年 1 月 30 ...

梅奥诊所（Mayo Clinic）的研究人员在《Nature Communications》期刊上发表了题为 “Lysosomal NKG7 restrains mTORC1 activity to promote CD8+ T cell durability and tumor control” 的论文 ... 来源的 CD8+ T 细胞、NK 细胞，以及 Jurkat CD4+ T ...

CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous ...

This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...

Typically, in advancing disease, as the immune system becomes exhausted, it is less able to produce T-cells to defend itself. The CD4/CD8 percentage helps healthcare practitioners see this.

CD4, and granzyme B but which did not express TRBC1 chain (a marker for expression of a T-cell antigen receptor constant beta chain; uniform positivity or negativity indicates clonality) or CD8.