Key signaling pathways driving renal cellular senescence include TGF-β/Smads, which induce p16/p21-mediated cell cycle arrest and SASP secretion. In unilateral ureteral obstruction (UUO) models, ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...

Researchers have identified a biological mechanism that helps explain why some lung and ovarian cancers become resistant to chemotherapy, offering insight into why cancers recur. The study, published ...