Researchers have used artificial-intelligence models to create regulatory DNA sequences that drive gene expression in specific cell types. Such synthetic sequences could be used to target gene ...

Professor Hirohide Saito (Department of Life Science Frontiers at CiRA / The University of Tokyo) and Assistant Professor ...

More information: Dennis Joshy et al, Accelerated cell-type-specific regulatory evolution of the human brain, Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2411918121 ...

Gene expression in the human brain: cell types become more specialized, not just more numerous. ScienceDaily . Retrieved June 11, 2025 from www.sciencedaily.com / releases / 2025 / 01 ...

A team of scientists at the MRC Laboratory of Medical Sciences (LMS) has uncovered a previously unknown mechanism that ...

The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can ...

For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes.

New AI model predicts gene expression across human cell types. Download PDF Copy; ... between DNA sequence and chromatin accessibility across large chunks of the genome in a specific cell type.

The study revealed several key insights. Across the three cell types, approximately 41.7% of the analyzed CREs exhibited activity. Promoters, which start gene transcription, showed a dependence on ...

Promoters, which start gene transcription, showed a dependence on sequence orientation but were less specific to cell types. Enhancers, which boost gene transcription, were active regardless of ...