Professor Hirohide Saito (Department of Life Science Frontiers at CiRA / The University of Tokyo) and Assistant Professor ...

A team of scientists at the MRC Laboratory of Medical Sciences (LMS) has uncovered a previously unknown mechanism that ...

A team of scientists at the MRC Laboratory of Medical Sciences (LMS) has uncovered a previously unknown mechanism that ...

More information: Dennis Joshy et al, Accelerated cell-type-specific regulatory evolution of the human brain, Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2411918121 ...

For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes.

The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can ...

This study demonstrates that Setd2 overexpression rescues bivalent gene expression during zygotic genome activation (ZGA) in ...

Fred Hutch researchers have created a gene-expression map of glial cells of the tiny worm, C. elegans, adding the missing ...

While physical activity is known to slow cognitive decline in Alzheimer’s disease, many patients are unable to exercise due ...

Moreover, the PTEN gene is known to regulate the development of inhibitory neurons. Therefore, a cell-type-specific ...

Gene delivery systems can target specific brain cells, a breakthrough that could lead to treatments for Parkinson's, Alzheimer's and other neurodegenerative diseases.