The biology of histone proteins encompasses their synthesis in the cytosol, nuclear import and incorporation into nucleosomes, as well as subsequent eviction from chromatin, redeposition, storage or ...

The journey by which proteins navigate their energy landscapes to their native structures is complex, involving (and sometimes requiring) many cellular factors and processes operating in partnership ...

Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer. Therefore, cells have mechanisms in place to control ...

In many neurodegenerative diseases like Parkinson's, protein aggregates form in the brain and are assumed to contribute to neuronal cell death. Yet there exists a cellular defence mechanism that ...

Proteins are the molecular machines of cells. They are produced in protein factories called ribosomes based on their blueprint, the genetic information. Here, the basic building blocks of proteins, ...

The protein UBR7 acts as a histone chaperone, regulating histone re-deposition at specific sites during DNA replication, according a recent study published in The EMBO Journal. This protein was ...

A team of researchers has announced a major new advance in understanding how our genetic information eventually translates into functional proteins -- one of the building blocks of human life. The ...

A new high-throughput study that used publicly available data shows that E. coli proteins containing a structure called a non-covalent lasso entanglement (NCLE) are more likely to misfold and, if they ...

In many neurodegenerative diseases like Parkinson's, protein aggregates form in the brain and are assumed to contribute to neuronal cell death. Yet there exists a cellular defense mechanism that ...