DECEMBER 3, 2025—(BRONX, NY)—Two related studies published today in Nature Metabolism show that a specialized intracellular recycling mechanism—chaperone-mediated autophagy (CMA)—is essential for ...

Two related studies published today in Nature Metabolism show that a specialized intracellular recycling mechanism—chaperone-mediated autophagy (CMA)—is essential for muscle health. Subscribe to our ...

Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...

The muscle damage that will weaken you at 60 may begin decades earlier. Not as soreness or fatigue, but as a microscopic cascade you cannot feel: damaged proteins piling up, calcium pumps seizing, the ...