Unraveling structure and function relationships in synthetic cell receptors
Northwestern University researchers have identified structural features in engineered cell receptors that correlate with ...
Hosted on MSN1d
Treating Generalized Myasthenia Gravis
Recently approved treatments for generalized myasthenia gravis (gMG), including complement and neonatal Fc receptor (FcRn) ...
Nature7y
IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fcγ-receptor or complement
IgG signals by binding to Fcγ receptors (FcγR) and by activating the complement system. The aim of our study was to investigate whether activation of FcγR and/or complement C3 mediates the ...
GEN15d
Obesity-Linked Hormone Adrenomedullin Disrupts Insulin Signaling
Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type ...
News Medical on MSN15d
A pathway that contributes to insulin resistance can be targeted, mouse study shows
The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...