Conformational changes in the bridging sheet and interdomain orientations are implicated in the mechanism of conformational masking, described by Kwong et al. 1. The dotted arrow represents the ...

How proteins in our cells attain their correct three-dimensional structure is crucial to their function—and to our health.

How proteins in our cells attain their correct three-dimensional structure is crucial to their function—and to our health.

A newly developed generative AI model is helping researchers explore protein dynamics with increased speed. The deep learning system, called BioEmu, predicts the full range of conformations a protein ...

Conformational changes in proteins, which occur at the nanoscale, are fundamental to processes ranging from enzyme catalysis and chemical signaling to cell division and differentiation.

Alan Cooper, Conformational fluctuation and change in biological macromolecules, Science Progress (1933-), Vol. 66, No. 264 (Winter 1980), pp. 473-497 Free online reading for over 10 million articles ...

Synopsis Conformational Design has played a key role in the medicinal chemistry of small molecule clinical candidates over the last 20 years. A key learning from multiple projects supported by ...