To prove this idea, researchers designed a very interesting experiment. They used formaldehyde to cross-link proteins to kDNA in a reversible fashion. Commonly used to preserve or fix tissues for ...

But what about protein occupancy in a living cell? Orlando and Paro's idea was simple: Crosslink protein-DNA complexes using formaldehyde, immunoprecipitate with an antibody to the protein of interest ...

A new technology developed at MIT enables scientists to label proteins across millions of individual cells in fully intact 3D tissues with unprecedented speed, uniformity, and versatility.