The supplement industry is booming—but so are serious health issues tied to taking these pills and powders. Here’s what ...

We identify drug metabolites from liver microsomes (e.g., mouse, rat, dog, and human) and in vivo studies. Identifying the unstable moieties can help guide the synthetic optimization of lead compounds ...

IMT was found to rewire liver metabolism to aid fatty acid degradation ... expression in the liver offer a potential strategy for drug therapy targeting obesity and associated pathologies.

Most drugs are metabolized by CYP3A enzymes, and variations in expression levels of these enzymes are believed to determine whether patients will have a positive or adverse drug response.

Drug-induced liver injury (DILI) is common because it can be caused by different pharmacological ... as they discuss the current understanding of the mechanisms that contribute to DILI and how ...

we assay stability in liver microsomes and perform reaction phenotyping against an array of CYP450s. Core personnel provide advice on the use of the supported methods for a wide variety of ...

Mirum Pharmaceuticals' Ctexli wins FDA approval for CTX, a rare lipid storage disease. The company projects 2025 global sales of $420–$435 million.

Next, Shulman and his team want to use their method to test the effects of these and other metabolism-related drugs on liver ...

Scientists from the University of California Davis have found that ibuprofen, a widely used painkiller, may have a bigger impact on the liver than previously thought. Their research also uncovered ...