E3泛素连接酶通过特异性识别底物调控蛋白质泛素化修饰，在细胞周期、免疫应答、代谢调控及神经退行性疾病中发挥核心作用。本文系统解析了HECT、RING、U-box及RBR型E3 ligases的结构与功能，阐明其在癌症（如通过MDM2降解p53）、心血管疾病（如WWP2介导的心肌纤维 ...

Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability. Researchers from the Bhogaraju Group at ...

This article and associated images are based on a poster originally authored by Poonam Shah, Mat Calder, Emma Stanway, Ben Durham, Aishwarya Sundaresh, Ásta-Björk Jonsdottir, Amy Prosser, Miguel ...