Abstract Summary Pharmacological enhancement of endoplasmic reticulum (ER) proteostasis is an attractive strategy to mitigate pathology linked to etiologically-diverse protein misfolding diseases.

With a new method, researchers have captured a high-resolution metabolic “map” of how cells orchestrate glucose processing, ...

The peripheral endoplasmic reticulum (ER) forms a continuous, dynamic network of tubules that plays an important role in protein transport and quality control, cellular signaling, and stress response.

We found that endoplasmic reticulum stress markers, activating transcription factor 6, inositol-requiring enzyme 1a, protein kinase RNA-like endoplasmic reticulum kinase, C/EBP homologous protein, and ...

Two junior research groups at Ruhr University Bochum, Germany, have developed a drug complex that kills cancer cells in such ...

Two junior research groups at Ruhr University Bochum, Germany, have developed a drug complex that kills cancer cells in such ...

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are essential for a wide range of cellular functions—as enzymes ...

The endoplasmic reticulum plays a more important role in type 2 diabetes and its complications than previously believed, new research suggests. To make their discovery, scientists identified ...

Results: Here, we show that ERO1A, an oxidoreductase involved in endoplasmic reticulum stress (ER stress)-induced apoptosis, instigates an immune-exclusive TME by transmitting ER stress to T cells. In ...

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