Here I discuss recent advances in the study of endoplasmic reticulum stress as one mechanism ... but it gradually compromises macrophage function, driving the cells to stress, inflammation and ...

A protein's function directly depends on its folded ... in the sarcoplasmic reticulum — a specialized type of endoplasmic reticulum found in muscle cells. Since calcium is essential for muscle ...

The peripheral endoplasmic reticulum (ER) forms a continuous ... how the unique structure of the ER arises and supports its function is critical to developing a mechanistic understanding of ...

The first clue about the possible connection between brain and muscle cells came when Janelia scientists noticed something strange about the endoplasmic reticulum, or ER – the membranous sheets and ...

The Jokitalo group studies structure-function interplay of organelles in mammalian cells. Our main model organelle is the endoplasmic reticulum. We employ a wide range of basic biological techniques ...

Our research group is investigating the signalling and biological functions of GDNF neurotrophic family ligands and endoplasmic reticulum located CDNF/MANF protein families, both within and outside of ...