Heparanase, the sole mammalian enzyme capable of cleaving heparan sulphate chains, is emerging as a central regulator of extracellular matrix (ECM) dynamics. By reshaping the ECM and modifying the ...

Growing from a single cell into a complex organism with specialized tissues and organs requires a complex and coordinated process. But the mechanical signals that guide tissue and organ ...

Inflammatory bowel disease (IBD) is typically diagnosed after the onset of symptoms in the context of established, characteristic patterns of intestinal inflammation. However, there is now substantial ...

Researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have discovered a specialized population of neutrophils in the skin that produce extracellular matrix components, helping ...

Researchers suggest targeting ECM-mediated regulation of autophagy levels could be used to sensitize pancreatic cancer to FDA-approved therapies.

Updated platforms are needed to accurately model renal fibrosis, a debilitating cause of chronic kidney disease ...

Immunology is a rich and diverse field involving numerous different elements and perspectives. For the majority of cases, research has heavily emphasized the details: discovering and elucidating ...

Cartilage injuries are a common clinical issue, often caused by trauma, severe infections, or degenerative joint diseases. The lack of direct blood supply to cartilage and limited access to nutrients ...

Researchers used advanced imaging to uncover early molecular changes in bone that may enable earlier diagnosis of ...

MASLD/MASH represents a growing clinical and economic burden, with MASH conferring heightened risks of advanced fibrosis, cirrhosis, hepatocellular carcinoma, and liver-related mortality. Noninvasive ...

All cells, from bacteria to mammalian cells, produce extracellular vesicles—tiny membrane-enclosed packages of bioactive cargo. 1 Until relatively recently, scientists believed these organic ...