Using phage display, they generated an FGFR3-specific monoclonal antibody (R3Mab) that had a similar affinity for human and mouse FGFR3. R3Mab blocked the activity of wild-type and mutant FGFR3 in ...
ETCTN 10483: Phase Ib trial of erdafitinib (E) combined with enfortumab vedotin (EV) following platinum and PD-1/L1 inhibitors for metastatic urothelial carcinoma (mUC) with FGFR3/2 genetic ...
A first-in-human phase 1 study of LY3866288 (LOXO-435), a potent, highly isoform-selective FGFR3 inhibitor (FGFR3i) in advanced solid tumors with FGFR3 alterations: Initial results from FORAGER-1.
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