Another promising avenue is the development of selective glucocorticoid receptor modulators (SGRMs). These compounds aim to provide the anti-inflammatory benefits of traditional glucocorticoids ...

ABBV-154, an antibody-drug conjugate comprising adalimumab conjugated to a proprietary glucocorticoid receptor modulator, shows potential for extending flare-free periods in patients with ...

Genetic defects that cause abnormalities in this receptor or in a protein required for its expression at the cell surface result in a potentially fatal disease (familial glucocorticoid deficiency).

Relacorilant is a selective cortisol modulator that binds to the glucocorticoid receptor but not to the body's other hormone receptors. The NDA is based on positive results from the GRACE trial ...

How do activation of glucocorticoid receptor-deficient T-cells and dysregulation of COX-2 activity cause mortality? Histological analyses of TGRKO and control mice treated with antibody to CD3ε ...