PTM, a rare manifestation of Graves' disease, involves an infiltrative lesion of the dermis and subcutaneous tissue, usually localized in the pretibial region.

CIRCUMSCRIBED pretibial myxedema is an unusual but not a particularly rare skin disease. In an excellent article Curtis and his associates1 described this condition, and many cases have been report ...

Orbitopathy is present In ∼ 50% of patients with Graves' disease, whereas pretibial myxedema and acropachy are rather rare.

Pretibial myxedema is one of the manifestations of Graves’ disease, an autoimmune disease manifested by hyperthyroidism, diffuse thyroid enlargement, infiltrative ophthalmopathy, acropachy, and ...

In all 10 patients with diffuse toxic goiter of Graves disease rendered euthyroid by radioiodine six months to six years earlier, myxedema (as evidenced by typical signs and symptoms, rises in seru ...

While there are reports of local trauma clearly contributing to the pathogenesis of pretibial myxedema, direct evidence for a similar mechanism in Graves' ophthalmopathy (GO) has been lacking.