Skin symptoms like redness, discoloration, and changes in texture are common with various forms of thyroid disease. A true pretibial myxedema rash, however, is now a fairly rare symptom ...

The role of iodine in thyroid function has intrigued investigators ... administration of iodine as a cause of both goiter and myxedema. The discovery by Plummer 2 (1923) that iodine would suppress ...