Through the deal, Celgene gains Gloucester's romidepsin (Istodax), a histone deacetylase (HDAC) inhibitor, which was approved by the FDA in November 2009 to treat cutaneous T cell lymphoma (CTCL ...

Concerns about HA-based HDAC inhibitors such as genotoxicity, rapid clearance and extensive metabolite formation, led CKD’s research team to identify a series of NHA molecules that selectively ...

HDAC inhibitors can be used as anti-cancer medication and could potentially help in the treatment of inflammatory diseases as well as neurodegeneration. With HDACs, which is found in plants and ...

HDAC inhibitors, conserved in plants and animals, are used as anti-cancer drugs and treat inflammatory diseases and neurodegeneration. When HDACs are inhibited, DNA gets less compactly wound in ...