Their findings, published in Genes and Development, provide insight into hepatocyte specialization that will aid efforts in regenerative medicine. The human liver performs over 150 specialized ...

An immortalized primary human hepatocyte cell line (HHL) was used to evaluate the effect of sTWEAK on triglyceride accumulation. Because of the burden of NAFLD in obesity, its association with ...

The growing emphasis on drug metabolism investigation has increased the demand for hepatocyte function studies in the pharmaceutical industries as well. The adoption of proper hepatocyte isolation ...

Over a 2-week course, most MAPC changed their phenotype and expressed multiple hepatocyte functions, including urea synthesis, albumin secretion, Phenobarbital-inducible cytochrome p450 induction ...

Researchers from the University of Illinois have identified a key process coordinating liver maturation and polyploidization, a state in which cells carry more than two sets of chromosomes.

A research team has identified the transcription factor Lhx2 (LIM homeobox protein 2) as a key regulator in hepatic stellate cells. Lhx2 was found to simultaneously promote liver regeneration and ...

This in turn contributes to the loss of hepatocyte microvilli and sinusoidal endothelial fenestrae, which result in deterioration of hepatic function. Kupffer cell (macrophage) activation ...

The growing emphasis on drug metabolism investigation has increased the demand for hepatocyte function studies in the pharmaceutical industries as well. The adoption of proper hepatocyte isolation ...