Their findings, published in Genes and Development, provide insight into hepatocyte specialization that will aid efforts in regenerative medicine. The human liver performs over 150 specialized ...

The growing emphasis on drug metabolism investigation has increased the demand for hepatocyte function studies in the pharmaceutical industries as well. The adoption of proper hepatocyte isolation ...

A research team has identified the transcription factor Lhx2 (LIM homeobox protein 2) as a key regulator in hepatic stellate cells. Lhx2 was found to simultaneously promote liver regeneration and ...

Over a 2-week course, most MAPC changed their phenotype and expressed multiple hepatocyte functions, including urea synthesis, albumin secretion, Phenobarbital-inducible cytochrome p450 induction ...

Under the right conditions, the cells differentiated into the two main cell types found in the liver, hepatocytes that carry out metabolic functions, and cholangiocytes, the cells that line the ...

This in turn contributes to the loss of hepatocyte microvilli and sinusoidal endothelial fenestrae, which result in deterioration of hepatic function. Kupffer cell (macrophage) activation ...

Researchers from the University of Illinois have identified a key process coordinating liver maturation and polyploidization, a state in which cells carry more than two sets of chromosomes.

The growing emphasis on drug metabolism investigation has increased the demand for hepatocyte function studies in the pharmaceutical industries as well. The adoption of proper hepatocyte isolation ...