Kupffer cells, hepatocytes, platelets, and leukocytes. Endothelial cells are also likely to participate in activation, both by production of cellular fibronectin and via conversion of transforming ...

and resident Kupffer cells (blue) and from injured hepatocytes (green). Oxidative stress, cytokine release, endotoxin, and ethanol and its metabolites can stimulate paracrine chemokine secretion ...

Non-parenchymal cells like hepatic stellate cells (HSCs), Kupffer cells (KCs), and liver sinusoidal endothelial cells (LSECs) play a key role in fibrosis development. These cells are involved in ...

3D validated cells Duo-culture Primary human hepatocytes + Kupffer Cells HBV, DILI, Immune-mediated toxicity PhysioMimix OOC, Liver plates, 3D validated cells Tri-culture Primary human hepatocytes ...

Alcohol metabolism in hepatocytes generates reactive oxygen ... liver cells and trigger immune responses. Activation of Kupffer cells (liver-resident macrophages) and hepatic stellate cells ...