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生物通
24 年
Nature子刊揭示染色体融合后染色体在核内的空间位置变化
在哺乳动物细胞核内,来源于不同染色体的线性 DNA 大分子会通过折叠形成染色体结构域( chromosome territories ),并在核内占据特定的位置。阐明核内染色体的结构与分布对理解其功能至关重要,这些功能包括 DNA 修饰与修复,以及基因转录活性的调控。近年来,随着技术的进步,如多染色体 FISH 和 Hi-C ...
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