为探究 ponatinib 与 imatinib 对费城染色体阳性急性淋巴细胞白血病（Ph + ALL）患者健康相关生活质量（HRQoL）的影响，研究人员开展 PhALLCON 试验。结果显示，ponatinib 在改善患者 HRQoL 等方面更具优势，这为 Ph + ALL 治疗提供了重要参考。

目的：探索使用伊马替尼（Imatinib）替代剂型治疗患者的可能性。方法：对两名患者使用不同的肠内和直肠伊马替尼剂型进行治疗。在治疗期间测量血浆浓度，以确保有足够的药物暴露量。结果：第一名患者通过十二指肠管接受伊马替尼悬浮液治疗。

Imatinib is a highly effective treatment for chronic myeloid leukaemia. However, patients often develop resistance to this ABL kinase inhibitor. This Review discusses second generation inhibitors ...

Learn about side effects, uses, cost, and more for imatinib oral tablets. This is a generic drug that treats certain types of cancer in adults and some children.

Imatinib also has limited activity against blast-phase CML and relapsed Ph-chromosome–positive ALL, conditions resistant to standard chemotherapy and even to allogeneic stem-cell transplantation.

Among patients with newly diagnosed chronic-phase CML who are receiving imatinib, the long-term outcome is more favorable for those in whom a complete cytogenetic response is achieved at 12 months ...

Nineteen patients with AF were treated with imatinib (800 mg/d) as part of a phase II clinical study. Tumor specimens were analyzed for mutations of KIT, PDGFRA, PDGFRB, and CTNNB1 (beta-catenin).

In this ongoing, multinational, phase III study, 536 patients with newly diagnosed chronic-phase CML were randomly assigned 1:1 to receive 400 mg of bosutinib once daily (n = 268) or imatinib (n = 268 ...

Imatinib has now been used by more than 100,000 patients worldwide, totaling more than 200,000 patient-years of exposure, she noted. Also, the CML patient population tends to be elderly, ...

Imatinib interruption should not be considered for patients with advanced gastrointestinal stromal tumor who do not have progressive disease, according to results of a randomized phase 3 trial ...

4 Consideration of the evidence. The Appraisal Committee reviewed the data available on the clinical and cost effectiveness of imatinib as an adjuvant treatment, having considered evidence on the ...