3、SQANTI Protein——全长蛋白质isoforms的新分类方案 根据ORF预测结果导出基因的蛋白isoforms模型，发现许多基因可以同时表达多种蛋白质亚型。 蛋白isoform分类考虑的是全长蛋白质序列，只能通过LR RNA-seq检测，这是只关注“局部”的技术例如的短读长RNA-seq和芯片技术所不能达到的。

Comparative analyses of isoforms can shed light on the functional importance of specific isoforms and their evolutionary dynamics. Precision medicine : Knowledge of gene isoforms can contribute to ...

These isoforms have been suggested as the reason for the occasionally observed opposing roles of STAT3 in cancer: an oncogene, on one hand, and a tumor suppressor on the other.

While all six isoforms are found in the adult human brain, adult mice normally express only 4R isoforms. Like humans, adult MAPT knock-in mice express all six tau isoforms, with the level of 4R mRNA ...

The method developed by Tripathi and colleagues detects isoforms as small as 0.1 ng/µL for supercoiled and linear isoforms, and 0.5 ng/µL for the circular isoform.

The CHOP team’s newly developed ESPRESSO tool has been designed to enable accurate discovery and quantification of RNA isoforms using error-prone long-read RNA sequencing data alone.

In this study, we show that pharmacological protein kinase C (PKC) activation induces cardiomyocyte hypertrophy via activation of novel PKC isoforms. Both neonatal rat ventricular cardiomyocytes and ...

14 Aug 2015. The C9ORF72 gene has been linked to both amyotrophic lateral sclerosis and frontotemporal dementia. Researchers trying to understand the function of the C9ORF72 protein have, until ...

Duron DI, et al. Inhibiting spinal cord-specific hsp90 isoforms reveals a novel strategy to improve the therapeutic index of opioid treatment. Sci Rep. 2024;14(1):14715. Streicher JM. The role of heat ...

In neurons, Tau (MAPT microtubule-associated protein tau) is a protein that binds to microtubules (the neuron’s transport system), which stabilizes their formation and maintenance. Tau is ...