Increased understanding of the biology of interleukin 17 (IL-17) has revealed that this cytokine is a central player in immunity at the sites most exposed to microorganisms. Although it has been ...

Interleukin-9 is a pleiotropic cytokine associated with allergic inflammation 1 and is a therapeutic target in patients with asthma. Its expression and that of the interleukin-9 receptor are greater ...

CI denotes confidence interval, and SNP single-nucleotide polymorphism. Sequencing reads were aligned to the hg19 reference genome. A SIFT (sorting intolerant from tolerant) score of less than 0.05 ...

A new study shows how two subsets of one type of immune cell -- the CD8 T cell -- develop to provide either short-term or long-term immune protection. The study focuses on one factor that guides that ...

B cells are known to generate antibodies through two different responses—an "emergency response" and an "everything is okay, let's prepare for the future response," says Mark Shlomchik, UPMC Professor ...

Profiling 523 cancer associated genes in circulating tumor DNA of children with CNS tumors. This is an ASCO Meeting Abstract from the 2021 ASCO Annual Meeting I. This abstract does not include a full ...

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family ...

Researchers have identified a novel strategy to reduce immune-related adverse events from immunotherapy treatment by targeting the cytokine interleukin-6 (IL-6). Researchers at The University of Texas ...

Interleukins (ILs), a group of cytokines, are produced by leukocytes and non-immune cells like endothelial, fibroblasts, smooth muscle, epithelial and bone marrow cells. 1 ILs mainly act as ...

Interleukin (IL)-1 is a prototypic proinflammatory cytokine. It is produced by numerous cell types (i.e., macrophages, synoviocytes, endothelial cells, chondrocytes, osteoclasts) and is found in ...

Studies show women experience longer-lasting pain than men due to biological differences in immune response and hormones. Research in Science Immunology found men’s testosterone boosts interleukin-10, ...