本研究针对肾上腺素过量使用引发多器官毒性这一临床难题，探讨了天然多酚化合物鞣花酸(Ea)的心脏保护作用机制。研究人员通过大鼠模型发现，Ea预处理能显著改善肾上腺素引起的心电图异常（心率下降、QT间期延长、ST段抬高），降低心脏损伤标志物（CK-MB ...
Shanghai Institute of Organic Chemistry has described oleanamide derivatives acting as Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (NFE2-related factor 2; ...
Work at Acelink Therapeutics Inc. has led to the identification of Kelch-like ECH-associated protein 1 (Keap1)/Nrf2 interaction inhibitors reported to be useful for the treatment of cancer, lung, ...
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