为解决肥胖背景下棕色脂肪组织（BAT）功能失调的免疫调控机制问题，意大利罗马第二大学团队开发单细胞分析工具MACanalyzeR，发现高表达PPARγ和GDF15的脂质相关巨噬细胞（LAMs）通过激活PPAR信号通路维持BAT产热特性，为代谢疾病治疗提供新靶点。该研究发表于《Nature Communications》。

本研究首先通过Bulk RNA-seq与scRNA-seq数据分析，明确了LAMs的表型特征及CD36在NAFLD各阶段的表达。为在体外模拟LAMs并研究CD36对其表型形成的影响，将 ...

Backoffice applications might be the best testing ground for LAMs, as they don’t expose the company to as much liability from an LLM going off the rails, PC says. Integrated ERP suites from large ...

LAMs bridge this gap by understanding the intent behind your request and taking the necessary steps to fulfill it. Large Language Models (LLMs) are no longer confined to the realm of science fiction.