Autophagy leads to the lysosomal degradation of cytosolic components and organelles. The best understood role for autophagy is directing the removal of damaged or unwanted products. Autophagy can be ...

Nutrient deprivation inhibits mTORC1 and activates AMPK, which then dephosphorylates or phosphorylates ULK1 at different sites, leading to the activation of the ULK complex and initiation of the ...