Oxidative stress arises when the production of reactive oxygen species (ROS) exceeds the capacity of antioxidant defences, leading to the oxidation of biomolecules such as lipids. Lipid peroxidation, ...

Timeline diagram depicting essential discoveries in the field of ferroptosis research. The exploration of ferroptosis originated from the identification of system xc-, which was initially reported in ...

Many different mechanisms have been suggested for the oxidative lipid fragmentations that produce biologically active aldehydes such as 4-hydroxynon-2-enal (HNE), oxononanoyl phosphatidylcholine ...

Junxia Min, Fudi Wang, et al., at Zhejiang University School of Medicine, China, provided an in-depth review on the programmed cell death known as ferroptosis, which is driven by iron-dependent lipid ...

Fukuoka, Japan—The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death. Controlled death of cells, or ...

For the first time, researchers have identified a previously unrecognized metabolic defense mechanism in aggressive brain tumors: a sugar-rich shield that surrounds tumor cells and protects them ...

It has been shown that silymarin is as active as quercetin and dihydroquercetin, and more active than quercitrin, in terms of antiperoxidant activity, independent of the experimental model used to ...