These observations have resulted in the hypothesis that bone marrow resident stem cells, specifically HSCs, are an important source for liver epithelial cell replacement, particularly during ...

Despite the evidence that HSCs are the primary cell type responsible for the emergence of bone marrow-derived liver epithelial cells in vivo, they are not the only bone marrow-derived cells that ...

which include a population of liver epithelial progenitors that can give rise to organoids capable of developing into hepatocytes or bile duct cells.

For the current study, they began by evaluating the epithelial factor ESRP2, a regulatory protein known to control RNA splicing in the liver. Absent in the fetus, ESRP2 is activated after birth. "We ...

A group of researchers in China have looked into the role of apolipoprotein B100 (ApoB100) in ovarian cancer following reports of excessive levels of ApoB100 inducing endoplasmic reticulum stress and ...