Non-parenchymal cells like hepatic stellate cells (HSCs), Kupffer cells (KCs), and liver sinusoidal endothelial cells (LSECs) play a key role in fibrosis development. These cells are involved in ...

It is a three-dimensional (3D) in vitro cell culture system based on primary human liver parenchymal cells (hepatocytes). The ...

Moreover, the cells and soluble factors participating in this response in liver are also similar to those in parenchymal injury to kidney, lung, or skin. Fibrosis occurs earliest in regions where ...

There is some controversy as to whether the halo is composed of compressed normal liver parenchyma ... including metastases from renal cell carcinoma, breast carcinoma, and islet cell tumors ...