The fight against cancer often begins with uncovering hidden players, and this study reveals one such key player: an unexpected class of abbreviated N-glycans. These molecules, upregulated in cancer ...

Lysosomes are surrounded by a lipid bilayer that separates the acidic environment and the digestive enzymes of the organelle from the cytoplasm. Damage to this layer - lysosomal membrane ...

Changes in Caenorhabditis elegans lysosome metabolism can be carried through generations via inherited histone modifications. A team of researchers from the Howard Hughes Medical Institute (MD, USA), ...

Researchers at The Hospital for Sick Children (SickKids) have found that inflammation in an immune cell may be responsible in part for some severe symptoms in a group of rare genetic conditions called ...

Lysosomes are thought of as cellular organelles that play an important role in recycling proteins and maintaning cells by breaking down stuff that isn’t needed. But new research has found that ...

Lysosomes are membrane-bound organelles whose acidic lumen (pH 4.5–5.0) is required for degradation. This luminal acidity is known to regulate cytosolic-side functions such as membrane fusion/fission, ...

The mechanism by which cells detect leaky lysosomes has been revealed, laying the groundwork for new treatments for diseases where lysosomal damage plays a central role. When the cell’s recycling ...