A complete set of chimeras was made between the lysosomal membrane glycoprotein LEP100 and the plasma membrane-directed vesicular stomatitis virus G protein, combining a glycosylated lumenal or ...

Michael N. Trinh, Michael S. Brown, Joseph L. Goldstein, Jaeil Han, Gonçalo Vale, Jeffrey G. McDonald, Joachim Seemann, Joshua T. Mendell, Feiran Lu Proceedings of the National Academy of Sciences of ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes. Lysosomes ...

In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, and their bones grow malformed. A lysosomal storage disorder, mucolipidosis type II causes edema of the internal ...

Scientists have uncovered an elegant biophysical trick that tuberculosis-causing bacteria use to survive inside human cells, ...

Lysosomes are membrane-bound organelles whose acidic lumen (pH 4.5–5.0) is required for degradation. This luminal acidity is known to regulate cytosolic-side functions such as membrane fusion/fission, ...

For the first time, the pathway through which cells repair damaged lysosomes has been observed and described. Lysosomes are the recycling center of a cell, where molecular waste is degraded into the ...

In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, and their bones grow malformed. In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, ...

Siglec-15 has traditionally been understood as an immune checkpoint molecule, primarily located on the cell membrane where it suppresses T-cell function. However, the new research revealed that in SHH ...

The mechanism by which cells detect leaky lysosomes has been revealed, laying the groundwork for new treatments for diseases where lysosomal damage plays a central role. When the cell’s recycling ...