The ability of lysosomes to move within the cytoplasm is important for many cellular functions. This ability is particularly critical in neurons, which comprise vast, highly differentiated domains ...

Organelles called lysosomes fuse with cargo-carrying vesicles and degrade the cargo molecules. How lysosomes maintain their size despite constant vesicle fusion was unclear, but now factors that aid ...

Lysosomes are membrane-bound organelles whose acidic lumen (pH 4.5–5.0) is required for degradation. This luminal acidity is known to regulate cytosolic-side functions such as membrane fusion/fission, ...