本周，《科学》期刊发布了一系列具有重大意义的研究成果，涉及包括医学、免疫学、生态学等多个领域，引发了众多科学家和公众的广泛关注。以下是对这些研究的详细解读，帮助读者更好地理解其背景和重要性。

撰文丨王聪编辑丨王多鱼排版丨水成文免疫疗法为癌症患者带来了巨大的希望，但癌症免疫疗法的总体效率仍然有限，许多癌症患者对癌症免疫疗法无反应。肿瘤诱导的免疫抑制是有效的肿瘤免疫治疗的关键障碍之一。肿瘤细胞能够利用不同的机制来营造独特的免疫抑制性肿瘤微环境 ...

肿瘤干细胞产生称为趋化因子的化学信号，吸引这个MDSC亚群，并为这些MDSC制造生长因子和激活因子。 通过构建基因工程小鼠模型，研究者观察到癌 ...

更令人振奋的是，研究小组发现胰高血糖素样肽1（GLP1）能够有效抑制CD8+T细胞中油酸的合成，进而减少了LCN2的产生。这一发现带来了翻天覆地的变化，研究人员利用一种编码GLP1的重组腺病毒（AdV-GLP1）进行实验，结果显示该策略显著降低了肿瘤微环境中PMN-MDSC的浸润，同时恢复了CD8+TILs的抗肿瘤活性。

The Multidisciplinary Success Center (MDSC) can be easy to miss as it’s tucked away on the third floor of the L building at LAC, yet the center has a multitude of different resources that could ...

Although the Pennsylvania Center for Dental Implants & Periodontics has been serving the Philadelphia region for more than 35 ...

Completing the Nagaland Chief Minister’s ambitious Multi-Disciplinary Sports Complex (MDSC) in Dimapur would reportedly ...

A type of aggressive, treatment-resistant brain tumor has a distinct population of immune cells that support its growth, according to new research led by investigators at the Johns Hopkins Kimmel ...

Searching for subtypes of immune cells seen only in the most serious, grade 4 brain tumors, called glioblastomas, and using a recently developed technology called spatial genomics, the researchers ...

A Shropshire swimming club is celebrating after seeing huge success at the 2025 county championships - including a total ...

A court has upheld a key defense procurement decision, ruling that a company taking part in a field hospital tender made ...