Macrocyclic compounds can block nearly 80% of cancer's signature characteristic events to control cancer occurrence and progression, suggesting a space for using macrocyclic compounds in cancer ...

2023年2月2日，该研究工作以Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P？Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance为题发表于Journal of Medicinal ...

Macrocyclic peptides are small chains of amino acids that form loops. The shape is important: it provides more surface area for the peptides to disrupt protein-protein interactions, and it helps ...

Reactions: How macrocyclic peptides compare with natural products, how C&EN can cover climate change stewardship, and how business is implicated in chemistry’s poor image.

Scientists have developed an innovative method to produce and rapidly analyze a vast array of macrocyclic peptides, molecules increasingly used in modern medicine. The research, published in Nature ...

Hepatocyte growth factor (HGF) is involved in cancer progression through MET receptor signaling. Here, HiP-8, a 12 amino-acid macrocyclic peptide, was identified to selectively recognize active HGF.

Macrocyclic peptides are promising candidates for pharmaceuticals, but their screening is difficult. Scientists have now developed an easy-to-use, high-throughput screening assay for cyclic ...

Macrocyclic and Supramolecular Chemistry Group; Contact information. Events & Exhibitions Royal Society of Chemistry, Thomas Graham House, Science Park, Milton Road, Cambridge CB4 0WF, UK Tel: +44 (0) ...

Idorsia Pharmaceuticals Ltd. has patented macrocyclic compounds acting as orexin OX2 receptor agonists reported to be useful for the treatment of obesity, pain, fatigue, inflammation, cognitive, sleep ...

Macrocyclic drugs are an emerging class of therapeutics that promise to open up drug target spaces which are poorly addressed by small chemical entities and larger biologics. Cyclosporin is the ...