Asthma a chronic respiratory condition may be driven by specific immune cells that influence inflammation and severity ...

8). Figure 8: Strategies to inhibit the allergic response underlying asthma. Anti-IgE. The release of mediators from mast cells in asthma is IgE-dependent, and blocking the activation of IgE using ...

Previous research indicates that mast cells, a type of immune cell found in the tissues throughout the body, cause ...

Thurmond has hit some bumps in the road in his journey exploring H4's relation to asthma. Early animal models suggested that this histamine receptor depended on mast cells, white blood cells that ...

J Med Genet., 42, e36 Evidence suggests that mast cells play a central role in the pathophysiology of asthma. Mast cells act as sensors of the environment to defend against damage and infection. They ...

Jasper Therapeutics, Inc. (Nasdaq: JSPR) (Jasper), a clinical stage biotechnology company focused on development of ...

4. Broader efficacy across indications: Success in multiple indications such as CSU, CIndU, and potentially asthma could establish briquilimab as a versatile treatment option, capturing a larger share ...

especially from mast cells. Increased risk of asthma-related events (death, hospitalizations, intubations) with LABA monotherapy (without ICS). Do not initiate in rapidly or acutely deteriorating ...

leading to the depletion of the mast cells via apoptosis which removes the underlying source of the inflammatory response in mast cell driven diseases such as chronic urticaria and asthma. Jasper is ...

to address mast cell driven diseases such as chronic spontaneous urticaria (CSU), chronic inducible urticaria (CIndU) and asthma, today announced that Jasper will host a virtual webinar on ...